A retrospective investigation of the effect of tranexamic acid application and tourniquet duration on postoperative bleeding amount in patients undergoing total knee arthroplasty

Objectives: It is aimed to investigate the effect of tourniquet and tranexamic acid (TXA) on amount perioperative bleeding in patients undergoing total knee arthroplasty. Methods: One hundred ninety-three included study. The study were divided into 4 groups. Group 1 (n = 78) was determined as patient group with long-term application, but without additional application accepted control group. 2 40) intravenous (IV) TXA applied group, 3 intra-articular 35) short-term (only cementing phase) IV difference between groups according use a during operation, method dose TXA, postoperative blood transfusion, drained blood, length hospital stay, complications investigated. Results: largest Hemoglobin (Hb) Hematocrit (Hct) decreases found (3.39 ± 0.92 g/dl 10.8%, respectively). Also highest drainage (median 350 ml), transfusion (16.7%), stay (mean 4.51 1.07 days) estimated loss 1559.8 ml) (p < 0.05). lowest Hb decrease 2.95 0.68 g/dl) 150 seen 3.89 0.8 Conclusions: shown lead reduction Hct, after surgery, stay. may be good option for